100000 - Document - Document and Entity Information
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100010 - Statement - Consolidated Balance Sheets
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100020 - Disclosure - Leases - Schedule of Future Maturities (Detail) 2
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100030 - Statement - Consolidated Balance Sheets (Parenthetical)
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100040 - Statement - Consolidated Statements of Operations
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100050 - Statement - Consolidated Statements of Stockholders' Equity
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100060 - Statement - Consolidated Statements of Stockholders' Equity (Parenthetical)
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100070 - Statement - Consolidated Statements of Cash Flows
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100080 - Disclosure - Overview
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100090 - Disclosure - Liquidity
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100100 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies
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100110 - Disclosure - Fair Value of Financial Instruments
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100120 - Disclosure - Other Financial Statement Details
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100130 - Disclosure - Warrants
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100140 - Disclosure - Leases
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100150 - Disclosure - Commitments and Contingencies
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100160 - Disclosure - Stockholders' Equity
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100170 - Disclosure - Income Taxes
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100180 - Disclosure - Net Loss per Share
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100190 - Disclosure - Defined Contribution Plan
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100200 - Disclosure - Subsequent Events
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100210 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies)
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100220 - Disclosure - Fair Value of Financial Instruments (Tables)
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100230 - Disclosure - Other Financial Statement Details (Tables)
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100240 - Disclosure - Warrants (Tables)
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100250 - Disclosure - Leases (Tables)
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100260 - Disclosure - Stockholders' Equity (Tables)
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100270 - Disclosure - Income Taxes (Tables)
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100280 - Disclosure - Net Loss per Share (Tables)
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100290 - Disclosure - Liquidity - Additional Information (Detail)
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100300 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Additional Information (Detail)
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100310 - Disclosure - Fair Value of Financial Instruments - Summary of Financial Instruments Measured at Fair Value on Recurring Basis (Detail)
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100320 - Disclosure - Fair Value of Financial Instruments - Additional Information (Detail)
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100330 - Disclosure - Fair Value of Financial Instruments - Summary of Changes in Fair Value of Level 3 Financial Instruments (Detail)
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100340 - Disclosure - Other Financial Statement Details - Schedule of Property and Equipment (Detail)
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100350 - Disclosure - Other Financial Statement Details - Additional Information (Detail)
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100360 - Disclosure - Other Financial Statements Details - Intangible Assets (Detail)
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100370 - Disclosure - Other Financial Statement Details - Future Amortization Expense (Detail)
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100380 - Disclosure - Warrants - Additional Information (Detail)
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100390 - Disclosure - Warrants - Fair Value of Convertible Preferred Stock Warrant Liability (Detail)
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100400 - Disclosure - Leases - Additional Information (Detail)
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100410 - Disclosure - Leases - Schedule of Components of Lease Expense (Detail)
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100420 - Disclosure - Leases - Schedule of Supplemental Cash Flow Information Related to Leases (Detail)
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100430 - Disclosure - Leases - Schedule of Future Maturities (Detail)
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100440 - Disclosure - Stockholders' Equity - Additional Information (Detail)
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100450 - Disclosure - Stockholders' Equity - Summary of Outstanding Common Stock Warrants (Detail)
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100460 - Disclosure - Stockholders' Equity - Summary of Stock Based Compensation Expense (Detail)
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100470 - Disclosure - Stockholders' Equity - Schedule of Fair Value of Award Granted Using Black-Scholes Option Pricing Model (Detail)
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100480 - Disclosure - Stockholders' Equity - Summary of Stock Option and Restricted Stock Unit Transactions (Detail)
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100490 - Disclosure - Stockholders' Equity - Summary of Restricted Stock Unit Transactions (Detail)
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100500 - Disclosure - Income Taxes - Schedule of Geographical Distribution of Loss before Income Taxes (Detail)
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100510 - Disclosure - Income Taxes - Provision for Income Tax Benefit by Applying Statutory Federal Income Tax Rate to Operating Loss (Detail)
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100520 - Disclosure - Income Taxes - Significant Components of Company's Deferred Tax Assets and Liabilities (Detail)
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100530 - Disclosure - Income Taxes - Additional Information (Detail)
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100540 - Disclosure - Income Taxes - Summary of Gross Unrecognized Tax Benefits (Detail)
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100550 - Disclosure - Net Loss per Share - Schedule of Weighted-Average Common Shares Outstanding (Detail)
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100560 - Disclosure - Net Loss per Share - Schedule of Potentially Dilutive Securities Outstanding Excluded from Computations of Diluted Weighted-Average Shares Outstanding (Detail)
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100570 - Disclosure - Defined Contribution Plan - Additional Information (Detail)
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100580 - Disclosure - Subsequent Events - Additional Information (Detail)
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Auditor Firm ID
Auditor Firm ID
2024
Lessee, Operating Lease, Liability, to be Paid, Year One
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Document Transition Report
Document Transition Report
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Options outstanding at end of period
Geographical [Axis]
Geographical
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Summary of Changes in Fair Value of Level 3 Financial Instruments
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses, other current assets and other assets
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units [Member]
Outstanding Restricted Stock Units [Member]
Issuance of restricted stock units shares under equity incentive plan.
Issuance Of Restricted Stock Units Shares Under Equity Incentive Plan
Issuance of restricted stock units under equity incentive plan (shares)
2025
Finite-Lived Intangible Asset, Expected Amortization, Year Two
Entity Public Float
Entity Public Float
Fair Value Disclosures [Text Block]
Fair Value of Financial Instruments
Income Tax, Policy [Policy Text Block]
Income Taxes
Property, Plant and Equipment, Useful Life
Estimated useful lives of property and equipment
Increase in right of use assets
Operating Lease Right-Of-Use Asset Increase
Operating lease right-of-use asset increase.
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase (decrease) in valuation allowance
Time Deposits, at or Above FDIC Insurance Limit
FDIC insurance limit
Subsequent Events [Text Block]
Subsequent Events
Proceeds from sale of common stock, common stock warrants and pre-funded stock warrants, net of issuance costs
Proceeds From Sale Of Common Stock, Common Stock Warrants And Pre-funded Stock Warrants, Net Of Issuance Costs
Proceeds from sale of common stock, common stock warrants and pre-funded stock warrants, net of issuance costs.
Operating Lease, Liability, Noncurrent
Long-term lease liabilities
Schedule of Stock by Class [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Total common stock warrant and contingent consideration liability
Liabilities, Fair Value Disclosure
Class of Stock [Line Items]
Assets, Current
Total current assets
Vesting [Domain]
Total liabilities and stockholders'equity
Liabilities and Equity
Entity Address, State or Province
Entity Address, State or Province
Fair value measurement with unobservable inputs reconciliation recurring basis liability expiration.
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Expiration
Expiration of warrants
2018 PIPE warrant liability.
Two Thousand Eighteen P I P E Warrant Liability [Member]
2018 PIPE Warrant Liability [Member]
2018 PIPE Warrants [Member]
Sale of common stock and issuance of common stock warrants and pre-funded common stock warrants, net of issuance costs
Stock Issued During Period, Value, New Issues
Stockholders' Equity Note, Stock Split, Conversion Ratio
Reverse stock split ratio
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Ending balance
Beginning balance
Proceeds from offering after deducting underwriting discount and other estimated offering expenses.
Proceeds From Offering After Deducting Underwriting Discount And Other Estimated Offering Expenses
Proceeds from offering after deducting underwriting discount and other estimated offering expenses
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value per option granted (in dollars per share)
Increase decrease in accrued clinical trial site costs.
Increase Decrease In Accrued Clinical Trial Site Costs
Accrued clinical trial site costs
Trading Symbol
Trading Symbol
Deferred Tax Assets, Net of Valuation Allowance
Total deferred tax assets
Common Stock, Shares, Issued
Common stock, shares issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Fair value of restricted stock units vested
Share based compensation arrangement by share based payment award options non vested aggregate intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Non Vested Aggregate Intrinsic Value
Aggregate Intrinsic Value
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Operating lease, expiration date
Lease Expiration Date
Foreign Tax Authority [Member]
Foreign Tax Authority [Member]
Shares, Outstanding
Balances at end (shares)
Balances at beginning (shares)
Capital Units, Authorized
Capital stock, shares authorized
Common Stock, Capital Shares Reserved for Future Issuance
Number of shares reserved for issuance
Entity Address, City or Town
Entity Address, City or Town
Deferred Tax Assets, Net of Valuation Allowance [Abstract]
Non-current deferred tax assets:
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Operating lease, weighted average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease, discount rate
Number of Common Warrant Shares
Number of Common Shares
Class of Warrant or Right, Outstanding
Balance at the end of period, in shares
Balance at the beginning of period, in shares
Unrecognized Tax Benefits Offset By Valuation Allowance
Unrecognized Tax Benefits Offset By Valuation Allowance
Unrecognized tax benefit offset by change in valuation allowance
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Options exercisable at end of period (shares)
Subsequent Event [Member]
Subsequent Event Type [Axis]
Finance Lease, Principal Payments
Financing cash flows from finance leases
Principal paid on finance lease liabilities
Share-Based Payment Arrangement, Tranche Two [Member]
Tranche B [Member]
Measurement Input, Expected Dividend Rate [Member]
Expected Dividend Yield [Member]
Paid-In Capital [Member]
Additional Paid-in Capital [Member]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Foreign rate differential
Amortization
Amortization
Amortization, Total
Liabilities, Current [Abstract]
Current liabilities
Assets, Current [Abstract]
Current assets
Counterparty Name [Axis]
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Statement of Stockholders' Equity [Abstract]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Options vested and expected to vest at end of period (in dollars per share)
Operating Lease, Liability, Current
Operating lease liabilities
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Fair Value of Convertible Preferred Stock Warrant Liability
Property, Plant and Equipment, Net
Property and equipment, net
Total
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Options vested and expected to vest at end of period
Increase in lease liability
Increase In Operating Lease Liability
Increase in operating lease liability.
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Entity Central Index Key
Entity Central Index Key
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of common stock purchased upon issuance of warrants
Number of common stock purchased upon issuance of warrants
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Weighted Average Grant Date Fair Value [Roll Forward]
Sharebased Compensation Arrangementby Sharebased Payment Award Options Nonvested Weighted Average Grant Date Fair Value Roll Forward
Weighted-Average Exercise Price per Share
Plan Name [Domain]
Plan Name
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Assets, Noncurrent [Abstract]
Long-term assets
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Warrants
Warrants [Member]
Warrants [Member]
Liabilities, Current
Total current liabilities
Entity Tax Identification Number
Entity Tax Identification Number
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Increase (Decrease) in Operating Capital [Abstract]
Change in operating assets and liabilities:
Asset purchase.
Asset Purchase [Axis]
Asset Purchase
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock based compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Weighted Average Remaining Contractual Term
Unrecognized assets and liabilities related to uncertain tax positions.
Unrecognized Assets And Liabilities Related To Uncertain Tax Positions
Unrecognized assets and liabilities related to uncertain tax positions
Operating loss carryforwards carried forward indefinitely.
Operating Loss Carryforwards Carried Forward Indefinitely
Operating loss carryforwards, carried forward indefinitely
Award Type [Axis]
Award Type
Finance Lease, Weighted Average Remaining Lease Term
Finance lease, weighted-average remaining lease term
Cash and Cash Equivalents [Abstract]
Class of Warrant or Right [Line Items]
Class Of Warrant Or Right [Line Items]
May 2023 Tranche B Warrants [Member]
May Two Thousand Twenty Three Tranche B Warrants [Member]
May two thousand twenty three tranche b warrants.
Plan Name [Axis]
Plan Name
Warrants expire term prior to anniversary date of issuance
Warrants Expire Term Prior To Anniversary Date Of Issuance
Warrants expire term prior to anniversary date of issuance
Geographical [Domain]
Geographical
Operating lease, term of contract
Lessee, Operating Lease, Term of Contract
Assets
Total assets
Exercise of warrants
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Exercise
Fair value measurement with unobservable inputs reconciliation recurring basis liability exercise.
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Future stock-based compensation for unvested employee options granted and outstanding
Entity Registrant Name
Entity Registrant Name
Components of Deferred Tax Assets [Abstract]
Exercise of warrants, shares
Exercise Of Warrants, Shares
Exercise of warrants.
Proceeds from issuance or sale of equity
Proceeds from issuance or sale of equity
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Number of shares issued upon full exercise of underwriters options to purchase additional shares.
Number Of Shares Issued Upon Full Exercise Of Underwriters Options To Purchase Additional Shares
Shares issued upon exercise of underwriters options
Share-Based Payment Arrangement, Expense, Tax Benefit
Income tax benefits recognized from stock-based compensation
Retained Earnings [Member]
Accumulated Deficit [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Ending balance
Beginning balance
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Tax (benefit) on the loss before income tax expense computed at the federal statutory rate
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Number of shares purchases by employees
Minimum [Member]
Minimum [Member]
Options exercisable at end of period
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Aggregate Intrinsic Value
Share based compensation arrangement by share based payment award options exercisable aggregate intrinsic value.
Proceeds from stock option exercises
Proceeds from Stock Options Exercised
Operating Lease, Liability
Total
Operating Lease, Liability, Total
Liabilities, Fair Value Disclosure [Abstract]
Liabilities
Patents and Merger Costs [Member]
Patents And Merger Costs [Member]
Patents and Merger Costs [Member]
Non-cash exercise of 2018 PIPE Warrants
Noncash Or Part Noncash Acquisition Noncash Financial Or Equity Instrument Consideration Warrants Exercised
Noncash or part noncash acquisition noncash financial or equity instrument consideration warrants exercised.
Share-Based Payment Arrangement, Tranche One [Member]
Tranche A [Member]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Equity Component [Domain]
Equity Component
Defined Contribution Plan, Cost
Matching contribution by Company
Employee Stock Option [Member]
Stock Options [Member]
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Class of Warrant or Right, Exercise Price Description
Class Of Warrant Or Right Exercise Price Description
Warrant issuance description
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Measurement Frequency [Axis]
Measurement Frequency
Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation
Tax withholding payments for net share-settled equity awards
Entity Current Reporting Status
Entity Current Reporting Status
Issuance of common stock
Common Stock, Shares Authorized
Common stock, shares authorized
Research and Development Expense
Research and development
Research and Development Expense, Total
Cash and Cash Equivalents [Line Items]
Cash And Cash Equivalents [Line Items]
Finance Lease, Right-of-Use Asset, after Accumulated Amortization
Finance lease right-of-use assets
Finance Lease, Right-of-Use Asset, after Accumulated Amortization, Total
Deferred Tax Liabilities, Gross
Total non-current deferred tax liabilities
Deferred Tax Liabilities, Gross, Total
Per share exercise price for Pre-funded warrant.
Per Share Exercise Price For Pre Funded Warrant
Per share exercise price for pre-funded warrant
Per share exercise price for pre-funded warrant
Assets [Abstract]
Assets
Proceeds from Issuance of Common Stock
Proceeds from sale of common stock, net of costs
Net proceeds from sale of common stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of shares available for grant
Measurement Input, Expected Term [Member]
Contractual Term [Member]
Common stock, $0.001 par value, 100,000,000 shares authorized, 31,678,159 and 8,159,382 shares issued and outstanding at December 31, 2023 and December 31, 2022, respectively.
Common Stock, Value, Issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term
Options exercisable at end of period
Weighted average remaining vesting period
Stockholders' Equity
Shareholders' Equity and Share-Based Payments [Text Block]
Furniture and Fixtures [Member]
Furniture and Fixtures [Member]
Cash paid for amounts included in measurement of lease liabilities.
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Cash paid for amounts included in the measurement of lease liabilities:
Current Fiscal Year End Date
Current Fiscal Year End Date
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense, Total
Auditor Name
Auditor Name
Operating Income (Loss)
Operating loss
Operating Income (Loss), Total
Two thousand twenty inducement equity incentive plan.
Two Thousand Twenty Inducement Equity Incentive Plan [Member]
2020 Inducement Equity Incentive Plan [Member]
Income Tax Expense (Benefit)
Provision for income tax benefit
Convertible Debt Securities [Member]
Warrants Issued to 2010/2012 Convertible Note Holders to Purchase Common Stock [Member]
Research and Development Expense [Member]
Research and Development [Member]
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decrease related to prior year tax positions
Ownership interest, percentage of voting rights of stock.
Ownership Interest Percentageof Voting Rightsof Stock
Ownership interest of voting rights of all classes of stock (percent)
Lessee, Leases [Policy Text Block]
Leases
Controlled Equity Offering Sales Agreement [Member]
Controlled Equity Offering Sales Agreement [Member]
Controlled equity offering sales agreement.
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Stock-based compensation expense
Tax withholding payments for net share-settled equity awards
Payment, Tax Withholding, Share-Based Payment Arrangement
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Vesting percentage
Measurement Input Type [Domain]
Measurement Input Type
Finite-Lived Intangible Assets, Net
Net Amount
Finite-Lived Intangible Assets, Net, Beginning Balance
Finite-Lived Intangible Assets, Net, Ending Balance
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Long-Lived Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Options outstanding at end of period
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowance
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increase related to current year tax positions
Other Nonoperating Income (Expense)
Interest income
Other Nonoperating Income (Expense), Total
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Change in value of liabilities
Operating lease, extension expiration
Lessee, Operating Lease, Extension Expiration, Month and Year
Lessee, operating lease, extension expiration, month and year.
Operating Expenses [Abstract]
Operating expenses
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction, Total
Entity Voluntary Filers
Entity Voluntary Filers
Subsequent Events [Abstract]
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Foreign
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Other Assets, Noncurrent
Other long-term assets
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Stock based compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of options granted
Options granted
Depreciation
Depreciation expense
Depreciation, Total
Patents And Trademark [Member]
Patents And Trademark [Member]
Patents And Trademark [Member]
2027
Finite-Lived Intangible Asset, Expected Amortization, Year Four
2024
Finite-Lived Intangible Asset, Expected Amortization, Year One
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Options exercisable at end of period (in dollars per share)
Offering costs
Stock Issued Issuance Costs
Stock issued issuance costs.
Equity, Attributable to Parent [Abstract]
Stockholders’ equity
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Lease, Cost [Table Text Block]
Schedule of Components of Lease Expense
Summary of Outstanding Common Stock Warrants
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Deferred Tax Assets, Capital Loss Carryforwards
Capital loss carryover
Earnings Per Share [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Operating Lease Liability Maturity
2014 equity incentive plan.
Two Thousand And Fourteen Equity Incentive Plan [Member]
2014 Equity Incentive Plan [Member]
Common Stock Warrant Liability [Member]
Common Stock Warrant Liability [Member]
Common stock warrant liability [Member]
Common stock warrant liability [Member]
Expiration of warrants.
Expiration Of Warrants
Expiration of warrants, in shares
Accounting Policies [Abstract]
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Proceeds from sale of common stock and pre-funded warrants
Proceeds From Sale Of Common Stock And Pre Funded Warrants
Proceeds from sale of common stock and pre-funded warrants.
Essentialis, Inc.
Essentialis Inc [Member]
Essentialis, Inc. [Member]
Liability Class [Axis]
Liability Class
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Equity Option [Member]
Options to Purchase Common Stock [Member]
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per common share basic
Schedule of Cash and Cash Equivalents [Table]
Schedule Of Cash And Cash Equivalents [Table]
Income tax reconciliation change in fair value of warrants.
Income Tax Reconciliation Change In Fair Value Of Warrants
Change in fair value of warrants
Commitments and Contingencies
Commitments and contingencies (Note 8)
Income Statement [Abstract]
Deferred tax assets lease liability.
Deferred Tax Assets Lease Liability
Lease liability
Performance Shares [Member]
Performance-Based Options [Member]
Sale of pre-funded warrants in public offering, net of issuance costs
Adjustments to Additional Paid in Capital, Warrant Issued
Operating Lease, Cost
Operating lease cost
Fair value measurement with unobservable inputs reconciliation recurring basis change in liability due to estimated future revenue milestones.
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Change In Liability Due To Estimated Future Revenue Milestones
Change in value of contingent liability due to estimated future revenue milestones
Short-Term Lease, Cost
Short-term lease cost
Retirement Benefits [Abstract]
Measurement Input Type [Axis]
Measurement Input Type
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Options vested and expected to vest at end of period (shares)
Statistical Measurement [Domain]
Statistical Measurement
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Net cash used in operating activities
Net cash used in operating activities
Prepaid Expenses And Other Current Assets Policy [Text Block]
Prepaid Expenses And Other Current Assets Policy [Text Block]
Prepaid Expenses and Other Current Assets
All Award Types
Award Type
Document Period End Date
Document Period End Date
Statistical Measurement [Axis]
Statistical Measurement
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Operating Lease, Payments
Operating cash flows from operating leases
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per common share diluted
Issuance of restricted stock units value under equity incentive plan,
Issuance Of Restricted Stock Units Value Under Equity Incentive Plan
Issuance of restricted stock units under equity incentive plan
Product and Service [Domain]
Deferred Tax Assets, Operating Loss Carryforwards
Federal and state net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Unrecognized Tax Benefits
Ending balance
Beginning balance
Internal Revenue Service (IRS) [Member]
Internal Revenue Service (IRS) [Member]
Debt Instrument, Name [Domain]
Debt Instrument, Name
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Derivative Liability, Noncurrent
Warrant liability
Fair Value, Recurring [Member]
Fair Value, Measurements, Recurring [Member]
Additional Paid in Capital, Common Stock
Additional paid-in-capital
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Deferred Tax Assets, Net
Net deferred tax assets
Finite-Lived Intangible Assets, Major Class Name [Domain]
Finite-Lived Intangible Assets, Major Class Name
Share based compensation arrangement by share based payment award options exercised intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Exercised Intrinsic Value
Stock options exercised, intrinsic value
Deferred tax assets, capitalized research and development.
Deferred Tax Assets, Capitalized Research And Development
Capitalized research and development
Exercise of stock options (shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Options exercised
Liabilities and Equity [Abstract]
Liabilities and stockholders’ equity
Finance lease cost.
Finance Lease Cost
Total finance lease cost
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Entity Interactive Data Current
Entity Interactive Data Current
Unrecognized tax benefits that would impact effective tax rate
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
2026
Finite-Lived Intangible Asset, Expected Amortization, Year Three
Increase (Decrease) in Employee Related Liabilities
Accrued compensation
Increase (Decrease) in Employee Related Liabilities, Total
Warrants and rights immediately exercisable term.
Warrants And Rights Immediately Exercisable Term
Warrants and rights immediately exercisable term
Text Block [Abstract]
Equity [Abstract]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less interest
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Stock units granted
Restricted stock units granted
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Options exercised (in dollars per share)
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering [Member]
Lessee operating and finance leases.
Lessee Operating And Finance Leases [Text Block]
Leases
Deferred tax liabilities right-of-use assets.
Deferred Tax Liabilities Right Of Use Assets
Right-of-use assets
Equity Components [Axis]
Equity Components
Increase (Decrease) in Other Operating Liabilities
Other liabilities
Increase (Decrease) in Other Operating Liabilities, Total
Retirement Benefits [Text Block]
Defined Contribution Plan
Deferred Tax Assets, Property, Plant and Equipment
Fixed assets
Expiration period
Expiration Date
Class of warrant or right warrants expiration month and year.
Class Of Warrant Or Right Warrants Expiration Month And Year
Sale and issuance of warrants
Proceeds from Issuance of Warrants
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Restricted stock units vested (in dollars per share)
Local Phone Number
Local Phone Number
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Sale of Stock [Axis]
Sale of Stock
Asset purchase.
Asset Purchase [Domain]
Asset Purchase
Research Tax Credit Carryforward [Member]
Research Tax Credit Carryforward [Member]
Statement of Cash Flows [Abstract]
Common stock, maximum aggregate purchase price
Common Stock Maximum Aggregate Purchase Price
Common stock, maximum aggregate value purchase price.
Income Tax Authority [Domain]
Income Tax Authority
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Document Annual Report
Document Annual Report
Common Stock, Par or Stated Value Per Share
Common stock, par value (in dollars per share)
Warrants exercised
Exercise of common stock warrants (shares)
Class of warrant or right exercised.
Class Of Warrant Or Right Exercised
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Future stock-based compensation, requisite service period
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Options vested and expected to vest at end of period
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Maximum [Member]
Maximum [Member]
Lessee, operating lease month and year of expiration.
Lessee Operating Lease Month And Year Of Expiration
Operating lease, expiration
Income Tax Contingency [Line Items]
Income Tax Contingency [Line Items]
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Summary of Gross Unrecognized Tax Benefits
Fair Value, Inputs, Level 3 [Member]
Level 3 [Member]
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Change in fair value of warrant liability
Fair Value Adjustment of Warrants
Change in fair value of common stock warrants
Issuance of common stock, warrants
Net increase (decrease) in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Purchase price contingent liability.
Purchase Price Contingent Liability [Member]
Purchase price contingent liability [Member]
General and Administrative Expense [Member]
General and Administrative [Member]
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of non-cash investing and financing information
Securities Purchase Agreement [Member]
Securities Purchase Agreement [Member]
Securities Purchase Agreement [Member]
Document Financial Statement Error Correction [Flag]
CALIFORNIA
Redwood City, California [Member]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Potentially Dilutive Securities Outstanding Excluded from Computations of Diluted Weighted-Average Shares Outstanding
City Area Code
City Area Code
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash flows from operating activities:
Schedule Of Significant Accounting Policies [Table]
Schedule Of Significant Accounting Policies [Table]
Schedule Of Significant Accounting Policies [Table]
Noncash lease expense.
Noncash Lease Expense
Noncash lease expense
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
March 2022 Warrants [Member]
March Two Thousand Twenty Two Warrants [Member]
March two thousand twenty two warrants.
Weighted-average common shares outstanding used to calculate basic shares
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted-average common shares outstanding used to calculate basic net loss per common share
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Amount
Other
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Amount, Total
Income tax reconciliation change in fair value of contingent consideration.
Income Tax Reconciliation Change In Fair Value Of Contingent Consideration
Change in fair value of contingent consideration
Cantor [Member]
Cantor Fitzgerald And Co [Member]
Cantor Fitzgerald and Co.
Employee Stock [Member]
Employee Stock Purchase Plan [Member]
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash flows from financing activities:
Research and Development Expense, Policy [Policy Text Block]
Research and Development
Lessee, Operating Lease, Description
Operating lease, description
2018 PIPE Warrants [Policy Text Block]
2018 PIPE Warrants [Policy Text Block]
2018 PIPE Warrants
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Unit Transactions
Lessee, operating lease commencement month and year.
Lessee Operating Lease Commencement Month And Year
Operating lease beginning date
Statement [Table]
Statement [Table]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option and Restricted Stock Unit Transactions
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Fair Value of Award Granted Using Black-Scholes Option Pricing Model
Document Fiscal Period Focus
Document Fiscal Period Focus
Lessee, Operating Lease, Liability, to be Paid
Total lease payments
2025
Lessee, Operating Lease, Liability, to be Paid, Year Two
Statement [Line Items]
Statement [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from computations of diluted weighted-average shares outstanding
Change in fair value of contingent consideration policy.
Change In Fair Value Of Contingent Consideration Policy [Text Block]
Change in Fair Value of Contingent Consideration
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Balance at end of period
Balance at the beginning of period
Payments to Acquire Furniture and Fixtures
Payment to acquire office furniture under operating lease
Subsequent Event [Line Items]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Significant Components of Company's Deferred Tax Assets and Liabilities
Derivatives, Policy [Policy Text Block]
Common Stock Purchase Warrants and Other Derivative Financial Instruments
Common Stock [Member]
Common Stock [Member]
Section 162(m) limitation
Income Tax Reconciliation Section One Sixty Two limitation
Income tax reconciliation section one sixty two limitation.
May 2023 Tranche B Pre-funded Warrants [Member]
May Two Thousand Twenty Three Tranche B Pre Funded Warrants [Member]
May 2023 Tranche B Pre-funded warrants.
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock Based Compensation Expense
Measurement Input, Risk Free Interest Rate [Member]
Risk-free Rate [Member]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
ASU No. 2016-13 [Member]
Accounting Standards Update 2016-13 [Member]
Income (Loss) from Continuing Operations before Income Taxes, Domestic
United States
Common Stock Warrant [Member]
Common Stock Warrants [Member]
Common stock warrants.
Other financial statement details disclosure.
Other Financial Statement Details Disclosure [Text Block]
Other Financial Statement Details
Cover
Cover [Abstract]
Vesting [Axis]
Document Fiscal Year Focus
Document Fiscal Year Focus
Intangible Assets, Finite-Lived, Policy [Policy Text Block]
Intangible Assets
Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to clinical trial services received from vendors, such as accrued contract research organization costs, patient costs, clinical site costs and clinical product cost. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued Clinical Trial Costs Current
Accrued clinical trial site costs
Shares issued from sale of common stock
Shares Issued From Sale Of Common Stock
Shares issued from sale of common stock.
Sale of Stock [Domain]
Sale of Stock
Other financial statement details disclosure.
Other Financial Statement Details Disclosure [Abstract]
Income Tax Contingency [Table]
Income Tax Contingency [Table]
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Restricted stock units granted (in dollars per share)
Weighted average grant-date fair value of all restricted stock units granted
Security Exchange Name
Security Exchange Name
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Contractual term of option
Domestic Tax Authority [Member]
U.S. Federal Jurisdiction [Member]
Class of warrants exercised.
Class Of Warrants Exercised
Warrants exercised
Recent Adopted Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Authorized
Convertible preferred stock, shares authorized
Preferred stock, shares authorized
Public Offering
Public Offering [Member]
Public Offering [Member]
Schedule of Finite-Lived Intangible Assets [Table]
Schedule Of Finite Lived Intangible Assets [Table]
Property, Plant and Equipment, Gross
Property and equipment, gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Operating lease right-of-use assets obtained in exchange for operating lease obligations
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Options canceled/forfeited (in dollars per share)
Warrants and Rights Outstanding, Term
Measurement term
Class of Warrant or Right [Table]
Class Of Warrant Or Right [Table]
Exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Entity Emerging Growth Company
Entity Emerging Growth Company
Amendment Flag
Amendment Flag
Tax Credit Carryforward, Amount
Tax credit carryforwards
Fair value measurement with unobservable inputs reconciliation recurring basis change in liability due to assignment of rights.
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Change In Liability Due To Assignment Of Rights
Change in value of contingent liability due to assignment of rights to Soleno
Schedule of Weighted-Average Common Shares Outstanding
Schedule of Weighted Average Number of Shares [Table Text Block]
Income tax reconciliation change in net operating loss.
Income Tax Reconciliation Change In Net Operating Loss
Change in net operating loss true up
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Change in research and development credits
Accounting Standards Update [Domain]
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Finance Lease, Right-of-Use Asset, Amortization
Amortization of right-of-use assets
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Schedule of Future Amortization Expense
Asset Acquisition, Contingent Consideration, Liability, Noncurrent
Contingent liability for Essentialis purchase price
Leases [Abstract]
Asset acquisition contingent consideration arrangements earn out payment,
Asset Acquisition Contingent Consideration Arrangements Earn Out Payment
Maximum potential cash earnout payments
Shares issued from sale of pre-funded warrants
Shares Issued From Sale Of Pre-Funded Warrants
Shares issued from sale of pre-funded warrants.
Entity File Number
Entity File Number
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Deferred Tax Assets, Gross
Gross non-current deferred tax assets
Finance Lease, Weighted Average Discount Rate, Percent
Finance lease, discount rate
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Cash and cash equivalents, end of period
Cash and cash equivalents, beginning of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Total
Exercise of common stock warrants
Exercise Of Common Stock Warrants
Exercise of common stock warrants.
Share-Based Payment Arrangement [Abstract]
Warrants and Rights Outstanding, Measurement Input
Measurement input
Accounts Payable, Current
Accounts Payable, Current, Total
Accounts payable,net
Debt Instrument [Axis]
Debt Instrument
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Ending balance (in dollars per share)
Beginning balance (in dollars per share)
Warrants expiration date
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Schedule of Intangible Assets and Goodwill [Table Text Block]
Schedule of Intangible Assets
Schedule of supplemental cash flow information related to leases.
Schedule Of Supplemental Cash Flow Information Related To Leases Table [Text Block]
Schedule Of Supplemental Cash Flow Information Related To Leases
Operating Expenses
Total operating expenses
Public offering price per pre-funded warrant.
Public Offering Price Per Pre Funded Warrant
Public offering price per pre-funded warrant
March 2022 Pre-funded Warrants [Member]
March Two Thousand Twenty Two Pre Funded Warrants [Member]
March two thousand twenty two pre funded warrants.
October 2023 Pre-funded Warrants [Member]
October Two Thousand Twenty Three Pre-funded Warrants [Member]
Oct 2023 Pre-funded warrants.
Auditor Location
Auditor Location
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected life (years)
Stockholders' Equity, Reverse Stock Split
Reverse stock split
Entity Address, Address Line Two
Entity Address, Address Line Two
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value; 10,000,000 shares authorized, no shares issued and outstanding
Entity Small Business
Entity Small Business
Entity Shell Company
Entity Shell Company
Number of Operating Segments
Number of operating segments
Contingent receipt upon exerise of warrants and future performance of company
Contingent Receipt Upon Exerise Of Warrants And Future Performance Of Company
Contingent receipt upon exerise of warrants and future performance oF company.
Weighted Average Exercise Price per Share
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price of warrants (in dollars per share)
Class of Warrant or Right [Domain]
Class of Warrant or Right
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock based compensation expense
Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation
Tax withholding payments for net share-settled equity awards (shares)
Liabilities, Noncurrent [Abstract]
Long-term liabilities
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted-average grant date fair value
Computer Equipment [Member]
Computer Hardware [Member]
Net Loss per Share
Earnings Per Share [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period
Options canceled/forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Total
Entity Address, Address Line One
Entity Address, Address Line One
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Antidilutive Securities [Axis]
Antidilutive Securities
Other Liabilities, Current
Other current liabilities
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Intangible Assets, Other than Goodwill
Net intangible assets acquired
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Intangible Assets, Other than Goodwill, Total
Measurement Input, Price Volatility [Member]
Volatility [Member]
Finite-Lived Intangible Assets, Gross
Amount
Finite-Lived Intangible Assets, Gross, Total
Concentration Risk, Credit Risk, Number of Banks
Concentration Risk Credit Risk Numberof Banks
Number of commercial banks
Milestones payment
Milestones Payment
Milestones payment.
Subsequent Event Type [Domain]
Her Majesty's Revenue and Customs (HMRC) [Member]
Her Majesty's Revenue and Customs (HMRC) [Member]
Offering costs
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Less transaction costs
Increase decrease in operating lease liabilities.
Increase Decrease In Operating Lease Liabilities
Operating lease liabilities
Income Statement Location [Axis]
Income Statement Location
Variable Lease, Cost
Variable lease cost
Two Thousand and Ten and Two Thousand and Twelve Convertible Promissory Notes [Member]
Two Thousand And Ten And Two Thousand And Twelve Convertible Promissory Notes [Member]
2010 and 2012 Convertible Promissory Notes [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Dividend rate
Expected dividend yield
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Income tax reconciliation change in capital losses.
Income Tax Reconciliation Change In Capital Losses
Change in capital losses
Product and Service [Axis]
Title of 12(b) Security
Title of 12(b) Security
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State tax (benefit) at statutory rate, net of federal benefit
Finite-Lived Intangible Assets, Accumulated Amortization
Accumulated Amortization
Exercisable warrants maximum aggregate exercise price.
ExercisableWarrants Maximum Aggregate Exercise price
Exercisable warrants maximum aggregate exercise price
Warrants To Purchase Stock [Member]
Warrants To Purchase Common Stock [Member]
Warrants to Purchase Stock [Member]
Schedule Of Significant Accounting Policies [Line Items]
Schedule Of Significant Accounting Policies [Line Items]
Schedule Of Significant Accounting Policies [Line Items]
Income Tax Authority, Name [Axis]
Income Tax Authority, Name
Accounting Standards Update [Axis]
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash flows from investing activities:
State and Local Jurisdiction [Member]
State Tax Jurisdiction [Member]
Segment Reporting, Policy [Policy Text Block]
Segments
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Fair Value, Liability, Recurring Basis, Unobservable Input Reconciliation, Gain (Loss), Statement of Income or Comprehensive Income [Extensible Enumeration]
Subsequent Event [Table]
Percentage of the probability of achieving the milestone.
Percentage Of Probability Of Achieving Milestone
Percentage of probability of achieving milestone
Underwriter [Member]
Underwriter [Member]
Underwriter [Member]
Warrants Issued to Underwriter to Purchase Common Stock [Member]
Deferred Tax Liabilities, Intangible Assets
Intangible assets
May 2023 Tranche A Pre-funded Warrants [Member]
May Two Thousand Twenty Three Tranche A Pre Funded Warrants [Member]
May two thousand twenty three tranche a pre funded warrants.
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Number of shares available for issuance under the plan on the first day of each year
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Restricted stock units cancelled/forfeited (in dollars per share)
Operating lease cost and sublease income.
Operating Lease Cost And Sublease Income
Total operating lease cost
Proceeds from warrant exercise
Proceeds from Warrant Exercises
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
Summary of Financial Instruments Measured at Fair Value on Recurring Basis
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Derivative Financial Instruments, Liabilities [Member]
Derivative Financial Instruments, Liabilities
Income Statement Location [Domain]
Income Statement Location
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Options granted (in dollars per share)
Two thousand and fourteen equity incentive plan and two thousand twenty inducement equity incentive plan.
Two Thousand And Fourteen Equity Incentive Plan And Two Thousand Twenty Inducement Equity Incentive Plan [Member]
2014 Plan and Inducement Plan [Member]
Document Type
Document Type
Document Type
Liquidity
Liquidity Disclosure [Text Block ]
Liquidity disclosure.
Warrants and rights exercisable term from following receipt of U.S. Food and drug administration approval.
Warrants And Rights Exercisable Term From Following Receipt of U.S. Food and Drug Administration Approval
Warrants and rights exercisable term from following receipt of U.S. Food and drug administration approval
Fair Value by Liability Class [Domain]
Fair Value by Liability Class
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Deferred Tax Assets, Tax Credit Carryforwards, Other
Other deferred tax assets
Counterparty Name [Domain]
Estimated warrants outstanding
Warrants and Rights Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Restricted stock units cancelled/forfeited
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Reverse stock split.
Reverse Stock Split Policy [Policy Text Block]
Reverse Stock Split
Entity Filer Category
Entity Filer Category
Income Tax Authority, Name [Domain]
Income Tax Authority, Name
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Geographical Distribution of Loss before Income Taxes
Class Of Warrant Or Right, Warrant Term
Class Of Warrant Or Right Warrant Term
Warrants term
Total other income (expense), net
Nonoperating Income (Expense)
Two thousand eighteen PIPE warrant liability to purchase common stock.
Two Thousand Eighteen P I P E Warrant Liability To Purchase Common Stock [Member]
2018 PIPE Warrant Liability [Member]
Deferred Tax Assets, Tax Credit Carryforwards
Research and other credits
Deferred Tax Assets, Tax Credit Carryforwards, Total
Capital Expenditures Incurred but Not yet Paid
Purchases of property and equipment in accounts payable
2028 and thereafter
Finite lived intangible assets amortization expense after year four.
Finite Lived Intangible Assets Amortization Expense After Year Four
Liabilities
Total liabilities
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Line Items]
Finite-Lived Intangible Asset, Useful Life
Estimated useful life
Total stockholders' equity
Equity, Attributable to Parent
Balances at ending
Balances at beginning
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Banking [Member]
Silicon Valley Bank [Member]
Intangible Assets, Net (Excluding Goodwill)
Intangible assets, net
Intangible Assets, Net (Excluding Goodwill), Total
Net Income (Loss)
Net loss
Net loss
Net loss
Other income (expense), net
Nonoperating Income (Expense) [Abstract]
Incentive Stock Options [Member]
Incentive Stock Options [Member]
ISOs [Member]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Business Description and Basis of Presentation [Text Block]
Overview
Proceeds from Issuance Initial Public Offering
Net proceeds from issuance of public offering
Deferred tax assets capitalized research and development expenses amortization period.
Deferred Tax Assets Capitalized Research And Development Expenses Amortization Period
Research and development costs, amortization period
March 2022 Common Warrants [Member]
March Two Thousand Twenty Two Common Warrants [Member]
March two thousand twenty two common warrants.
Statement of Financial Position [Abstract]
Basis of Presentation and Summary of Significant Accounting Policies
Basis of Presentation and Significant Accounting Policies [Text Block]
Area of Real Estate Property
Area of operating lease
Shares granted to date
Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture
Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture, Total
Weighted-average common shares outstanding used to calculate diluted shares
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted-average common shares outstanding used to calculate diluted net loss per common share
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Provision for Income Tax Benefit by Applying Statutory Federal Income Tax Rate to Operating Loss
Shares Issued, Price Per Share
Price per unit
Warrant Liability Disclosure [Text Block]
Warrant Liability Disclosure [Text Block]
Warrants
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Reserves and accruals
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Operating lease remaining term
Operating Lease, Weighted Average Remaining Lease Term
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Percentage of fair market value
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Income Tax Disclosure [Text Block]
Income Taxes
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Ending balance (in dollars per share)
Beginning balance (in dollars per share)
Finite-Lived Intangible Assets [Line Items]
Finite Lived Intangible Assets [Line Items]
May 2023 Tranche B Pre-funded Exchange Warrants [Member]
May Two Thousand Twenty Three Tranche B Pre Funded Exchange Warrants Member
May two thousand twenty three tranche B pre funded exchange warrants.
Income Tax Authority [Axis]
Income Tax Authority
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Sale and issuance of warrants to purchase common stock
Stock and Warrants Issued During Period, Value, Preferred Stock and Warrants
Fair Value Disclosures [Abstract]
May 2023 Tranche A Pre-funded Exchange Warrants [Member]
May Two Thousand Twenty Three Tranche A Pre Funded Exchange Warrants Member
May two thousand twenty three tranche A pre-funded exchange warrants.
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Percentage of outstanding stock maximum
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Measurement Frequency [Domain]
Measurement Frequency
Income tax reconciliation change in state rates.
Income Tax Reconciliation Change In State Rates
Change in state rates
Asset acquisition contingent consideration change in fair value.
Asset Acquisition Contingent Consideration Change In Fair Value
Change in fair value of contingent consideration
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Finance Lease, Interest Expense
Interest on lease liabilities
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Restricted stock units vested
Sale of common stock and issuance of common stock warrants and pre-funded common stock warrants, net of issuance costs (shares)
Stock Issued During Period, Shares, New Issues
Issuance of common stock (shares)
Employee-related Liabilities, Current
Accrued compensation
Employee-related Liabilities, Current, Total
Class of Warrant or Right [Axis]
Class of Warrant or Right
Income Tax Disclosure [Abstract]
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets by Major Class
Proceeds from exercise of common stock warrants and pre-funded stock warrants, net of costs
Proceeds From Exercise Of Common Stock Warrants And Pre-funded Stock Warrants, Net Of Costs
Proceeds from exercise of common stock warrants and pre-funded stock warrants, net of costs.
Operating Loss Carryforwards
Operating loss carryforwards