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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2021-03-02T00:01:47.0633471+00:00 -->
<!-- Version            : 5.0.1.571 -->
<!-- Package ID         : 3dbb7530206b4fcb8674c809d8d0a76d -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="slno_IncentiveStockOptionsMember" name="IncentiveStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_TwoThousandAndFourteenEquityIncentivePlanMember" name="TwoThousandAndFourteenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_TwoThousandTwentyInducementEquityIncentivePlanMember" name="TwoThousandTwentyInducementEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_SeriesDWarrantsMember" name="SeriesDWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_WarrantsToPurchaseCommonStockMember" name="WarrantsToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_UnderwriterMember" name="UnderwriterMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_TwoThousandAndTenAndTwoThousandAndTwelveConvertiblePromissoryNotesMember" name="TwoThousandAndTenAndTwoThousandAndTwelveConvertiblePromissoryNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_AssetAcquisitionNumberOfSharesIssued" name="AssetAcquisitionNumberOfSharesIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="slno_AssetAcquisitionContingentConsiderationArrangements" name="AssetAcquisitionContingentConsiderationArrangements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="slno_ProceedsFromIssuanceOrSaleOfEquityGross" name="ProceedsFromIssuanceOrSaleOfEquityGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_NumberOfSharesIssuedUponFullExerciseOfUnderwritersOptionsToPurchaseAdditionalShares" name="NumberOfSharesIssuedUponFullExerciseOfUnderwritersOptionsToPurchaseAdditionalShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="slno_OwnershipInterestPercentageofVotingRightsofStock" name="OwnershipInterestPercentageofVotingRightsofStock" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="slno_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsVestedinPeriodWeightedAverageRemainingContractualTerm" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsVestedinPeriodWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="slno_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAggregateIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAggregateIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonVestedAggregateIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonVestedAggregateIntrinsicValue" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_ClassOfWarrantsExercised" name="ClassOfWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="slno_ClassOfWarrantOrRightWarrantsExpirationMonthAndYear" name="ClassOfWarrantOrRightWarrantsExpirationMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="slno_IncomeTaxReconciliationChangeInFairValueOfWarrants" name="IncomeTaxReconciliationChangeInFairValueOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_IncomeTaxReconciliationChangeInFairValueOfContingentConsideration" name="IncomeTaxReconciliationChangeInFairValueOfContingentConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_IncomeTaxReconciliationChangeInNetOperatingLoss" name="IncomeTaxReconciliationChangeInNetOperatingLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="slno_IncomeTaxReconciliationChangeInStateRateTrueUp" name="IncomeTaxReconciliationChangeInStateRateTrueUp" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_DeferredTaxAssetsLeaseLiability" name="DeferredTaxAssetsLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_DeferredTaxLiabilitiesRightOfUseAssets" name="DeferredTaxLiabilitiesRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="slno_OperatingLossCarryforwardsCarriedForwardIndefinitely" name="OperatingLossCarryforwardsCarriedForwardIndefinitely" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="slno_UnrecognizedAssetsAndLiabilitiesRelatedToUncertainTaxPositions" name="UnrecognizedAssetsAndLiabilitiesRelatedToUncertainTaxPositions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="slno_UnrecognizedTaxBenefitsOffsetByValuationAllowance" name="UnrecognizedTaxBenefitsOffsetByValuationAllowance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="slno_SeriesCWarrantToPurchaseCommonStockMember" name="SeriesCWarrantToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="slno_SeriesDWarrantToPurchaseCommonStockMember" name="SeriesDWarrantToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
